Pain is relative, but…yes. It’s not unbearable, but it’s not exactly fun, either. In general, it is more painful if your system is already stressed for any reason. If you are sick, hungover, lacking sleep, etc. it will probably hurt more. The best thing you can do is get a good nightʼs sleep, eat properly beforehand, drink plenty of water, and relax. Do not take any medication or drink alcohol that will thin out your blood!